LDL

Globally, deaths arising from raised cholesterol levels reads at 2.6 million and this is sad. What’s sadder is the fact that about 10% of these people didn’t realize they have it; even the ones still alive.

Cholesterol might either be termed good or bad and many factors can influence the levels of cholesterol in your blood especially genetics.

Apart from lifestyle, diet and exercise, genetics could be a risk factor for increased cholesterol levels. If a family member has high cholesterol levels, there is every tendency you might have it especially if you don’t pay attention to lifestyle matters.

This phenomenon is termed “familial” since it runs in a family.

SOME FACTS ABOUT FAMILIAL HYPERCHOLESTEROLAEMIA

– 1 person in every 500 persons has it

– Doesn’t have symptoms, but these signs like deposits of cholesterol in skin and tendons could be notice

– Only 10%-20% of people with it know they have it

– Individuals with familial hypercholesterolaemia will pass it on to their children

IS THERE A DIFFERENCE BETWEEN FAMILIAL HYPERCHOLESTEROLAEMIA AND NORMAL HYPERCHOLESTEROLAEMIA?

If high levels of cholesterol occur in any relative of yours, such as a parent, sibling, or grandparent, you’re more likely to have it yourself. This occurrence is totally due to the passing on of genes from parents to children that increase levels of cholesterol in the blood.

Familial hypercholesterolaemia is more like an inherited form of hypercholesterolaemia. People with this type of conditions normally would have high cholesterol levels even with a lifestyle modification. Simply because they don’t have the capacity to regulate their cholesterol levels as other individuals.

There is every tendency that people with familial hypercholesterolaemia might not be able to control their cholesterol levels with just diet and exercise alone, but with medications too.

You should also note that not everyone with a high risk of developing high cholesterol actually has their cholesterol levels sky rocketing.

HOW DO I KNOW IF I HAVE FAMILIAL HYPERCHOLESTEROLAEMIA

One of the major ways to ascertain if you have high cholesterol levels especially if it’s a familial case is through a lipid screening test. This measures the amount of cholesterol in your blood.

Ideally, signs to look out for in adults are cholesterol levels above 190mg/dl and levels above 160mg/dl in children.

In addition, your doctor might help detect physical signs, which might not be common to everyone. These signs includes:

– Bumps or lumps around your knees, knuckles, or elbows

– Swollen or painful Achilles tendon

– Yellowish areas around your eyes

– A whitish grey colour in the shape of a half-moon on the outside of your cornea

WHAT CAUSES FAMILIAL HYPERCHOLESTEROLAEMIA?

This type of cholesterolaemia is a genetic one meaning it is hereditary and is caused by a defect on chromosome 19.

Your body finds it difficult to remove LDL cholesterol from the body making it easy for the narrowing of vessels which might possibly lead to atherosclerosis. You just need to get an abnormal gene from one family member to get this disease.

WHAT ARE THE RISK FACTORS AND HOW DO I MANAGE THEM?

1. OBESITY OR HIGH WAIST CIRCUMFERENCE: Both obesity and a high waist circumference can increase your risk for high cholesterol.

Obesity is defined as a body mass index (BMI) of 30 or higher, while a high waist circumference is 40 or more inches for men and 35 or more inches for women.

If you have a family history of hypercholesterolaemia, then you should be careful so fat wont be unevenly distributed in your body. When fat accumulates in only one part of the body, especially in the abdominal region, it can lead to an increased risk of developing hypercholesterolaemia and other cardiovascular complications.

2. ELEVATED BLOOD SUGAR

As someone with a family history of hypercholesterolaemia, you should also be aware of your glucose levels as high levels of glucose can increase LDL cholesterol and decrease HDL cholesterol, damage the lining of arteries and also increase your risk of fatty deposits building up in your arteries.

Lifestyle choices, like diets high in soda, candy, or other foods containing large amounts of sugar, can also contribute to high blood sugar levels.

Reducing your intake of these things that contribute to an increased glucose level is key to reducing the risks of high cholesterol levels. An increased fibre intake of at least 30-35g of fibre daily would help to keep glucose levels in check.

3. LIFESTYLE FACTORS

If you have a family history of high cholesterol, you should consider some modifications to your lifestyle as it totally affects your chances to also get the disease. Diet, exercise and social vices are risk factors associated with high cholesterol. They can be controlled by modifying your lifestyle.

– Eating a diet high in saturated and trans fats can increase your cholesterol levels. These highlighted foods should be taken away from your diet totally or restricted to the barest minimum if you have a history of high cholesterol in the family.

• red meat

• full-fat milk and yogurt

• fried foods

• highly processed sweets

More so, adding foods that are cholesterol reducing would help reduce the risks of developing high cholesterol. Foods like nuts, beans, whole grains, fruits, vegetables, green vegetables, lentils, oatmeal, whole grain breads, low-fat dairy, low-fat meats, such as poultry are helpful.

– Exercise has the tendency to help increase your HDL cholesterol and decrease your LDL cholesterol. If you can aim at 150 minutes of moderate to intense aerobic exercise weekly, then you’re on journey to increasing you HDL levels which helps to reduce risk for developing high cholesterol and other coronary diseases.

If you just want to start, you can try out walking a distance first before doing other types of exercise so as not to get fagged out easily.

– Tobacco Smoking damages the wall of your blood vessels and is detrimental to your heart health. This makes it more likely for fat deposits to build up, thereby increasing your risk of high cholesterol levels.

CONCLUSION

Apart from other risk factors, genetics is a major risk factor related to high cholesterol levels. It is very important to be aware of this condition especially if it runs in your family and also aware of measures to curb its progression.

SOURCES

1. https://www.healthline.com/health/high-cholesterol/is-high-cholesterol-hereditary#outlook

2. https://www.health.harvard.edu/heart-health/when-very-high-cholesterol-runs-in-the-family-

3. https://medlineplus.gov/ency/article/000392.htm#:~:text=Familial%20hypercholesterolemia%20is%20a%20genetic,of%20LDL%20in%20the%20blood.

4. https://www.cdc.gov/cholesterol/facts.htm

 

 

 

 

 

 

Fructose is a type of sugar known as a monosaccharide (single sugar), which is the building block of carbohydrates. All carbohydrates provide four calories per one gram, including fructose.

Fructose is commonly referred to as ‘fruit sugar’ because it primarily occurs naturally in fruits and other plants as sugar cane and vegetables. You can also get fructose from honey, sugar beets and sugar cane.
fructose is 1.2-1.8 times sweeter than the regular table sugar (sucrose). It is actually the sweetest naturally occurring carbohydrate.

During its breaking down process in the body, insulin is not required, and it tends to have a low impact on blood glucose.
It’s process of digestion differs from other types of carbohydrates.

Fructose and glucose are both single sugars and have been found to have the same chemical formula but different structures, making fructose sweeter than glucose.
Fructose occurs in plants and fruits but not alone, it always occurs with other types of sugars.

Where does fructose come from?

“Fruit sugar” as it is sometimes referred to, is a naturally occurring sugar found primarily in fruits (such as apples, dates, figs, pears and prunes), and also can be found occurring in vegetables (such as artichokes, asparagus, mushrooms, onions and red peppers), honey, sugar beets and sugar cane. “Pure fructose is produced commercially from corn or sucrose into a crystalline form for use as an ingredient in packaged foods and beverages”.
Although fructose is in high fructose corn syrup (a 55:45 mixture of the monosaccharides fructose and glucose), crystalline fructose should not be confused with high fructose corn syrup.

Is fructose a natural or added sugar?
Fructose can either be a natural sugar or an added sugar, it all lies solely on the source. It is considered a natural sugar when we consume it directly from whole plant foods or fruits, then, it is considered an added sugar when we consume from packaged foods, beverages which high fructose corn syrup has been added to during manufacturing.
While there is really no recommendation for fructose consumption, current dietary guidance recommends limiting the consumption of added sugars to less than 10% of total calories—in other words, i.e < 50 grams of added sugars if you consume 2,000 calories per day.

How is fructose digested?
Fructose has raised so much dust and debates among nutrition scientists because of the unique way the body handles it. It is somewhat digested in a different manner from other sugars, leading scientists to question its role in health. A 2016 review concluded that while fructose does not appear to have a unique impact on health, “fructose-containing sugars can lead to weight gain, increase in cardiometabolic risk factors and disease only if it provides the excess calories.”
No matter the source of the fructose, be it directly from plants or beverages, fructose when consumed is handled by the liver. The liver converts it to energy sources for bodily processes and doesn’t require insulin for this process. Unlike glucose which is released into the tissues by the help of insulin.
Some people have trouble absorbing fructose when eating it in large amounts and some are unable to absorb fructose at all. About one in 20,000–30,000 people are born with HFI each year. Because individuals with HFI (hereditary fructose intolerance) cannot metabolize fructose, foods and beverages containing fructose, sucrose or the sugar alcohol sorbitol must be avoided totally.

Are there health implications of fructose?
The rise in concern of added fructose to carbonated drinks and its direct link with obesity has led to a huge questioning on the impacts of fructose.
Although fructose might not really have adverse impact on blood sugar, it would have very detrimental effects on weight, LDL levels, triglyceride levels if taken in excess as added sugar from beverages and packaged foods.
According to recent research, fructose intake has been linked to uric acid levels, higher risks of gout development in men.
Due to the increase in use of fructose as sweetener, overconsumption is inevitable, thereby leading to detrimental health effects.

Why is fructose added to foods and beverages?
One major reason for adding sugar to packaged foods and beverages is its sweet taste. To sell, you have to make the product appealing to the taste buds yes?
The sweetness of fructose also has a fading ability, meaning that it doesn’t last for a long period after consumption.
Well, this doesn’t stop the fact that it still contains calories like other carbohydrates.
Other reason why fructose is added to beverages includes:
– Its hygroscopic nature which helps it absolve water, thereby improving texture.
– Fructose is also a good humectant; it can help retain moisture which could help improve and extend shelf life.

SUMMARY
Fructose is a naturally occurring sugar found in fruits and plants. It can be beneficial to health if consumed from natural sources than when it is an added sugar. Overconsumption of beverages and carbonated drinks would have very adverse effects on the health than give benefits. Its better to stick to natural sources of fructose.

SOIURCES: https://foodinsight.org/what-is-fructose/
https://www.acs.org/content/acs/en/molecule-of-the-week/archive/f/fructose.html
https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-7-82