Gut

Cancer has been a threat globally and every professional has been on their toes to proffer a solution.
Immunotherapy, therefore, is one of the ways to help manage cancer patients
Immunotherapy involves stimulation of the immune system to help fight cancer. This method has shown tremendous improvements in the treatment of many tumors.

Even with this development, there are individual responses to the treatment. For some people, the tumors might shrink or disappear totally, and for some, no effects at all.

Further research has gone into this case, and it has been noticed that the gut microbiome might have a role to play in the efficacy of immunotherapy. So, therefore, modifying the gut bacterium may help improve tumor response to immunotherapy.

FIBER INTAKE AND MELANOMA RISK

According to a study, a higher intake of dietary fiber (responsible for the promotion of healthy gut) was associated with improved response to immunotherapy, and in preclinical models, dietary fiber manipulation impacted antitumor immunity. According to Jennifer McQuade, MD, assistant professor of melanoma medical oncology at The University of Texas MD Anderson Cancer Center, “The dietary pattern associated with response to immunotherapy is the same diet recommended by American Cancer Society and American Institute for Cancer Research, which includes a diet rich in fruits and vegetables, whole grains and legumes. This diet is also recommended for secondary cancer prevention and prevention of cardiovascular disease and health in general.”
Furthermore, research has it that every 5% increase in fiber intake resulted in a 30% reduced risk of cancer progression or death.

RATIONALE
Previous research has shown gut microbes may regulate response to drugs that block protein (T-cells) checkpoints. Extensive studies on the effect of diet and probiotic supplements on patients with melanoma using drugs that inhibit these proteins are needed.

METHODOLOGY
McQuade and colleagues conducted a randomized prospective clinical trial to assess how varying fiber intake affects the gut microbiome and immune response among 128 patients with advanced melanoma receiving treatment with immune checkpoint inhibitors.

Researchers examined fecal microbiota profiles, dietary habits, and commercially available probiotic supplement use, and performed parallel preclinical studies.

KEY FINDINGS
According to a randomized prospective clinical trial to assess how varying fiber intake affects the gut microbiome and immune response among 123 patients with advanced melanoma, Patients who reported higher consumption of dietary fiber intake from fruits, vegetables, legumes, and whole grains experienced significantly longer PFS. Median PFS was not reached among the 37 patients with sufficient fiber intake, compared with median PFS of 13 months among the 91 patients with insufficient fiber intake.
After this, it was noticed that 82% of patients with both sufficient fiber intake and no probiotic use responded well to immunotherapy, compared with only 59% of patients who reported either insufficient fiber intake or probiotic use.
Probiotic supplement use alone did not appear associated with a significant difference, in short, data suggests it reduces chances of survival.

IMPLICATIONS
Based on these findings, oncologists, dietitians, and all others managing cancer patients, it is important to focus on how much fiber is consumed in their diet.
The aim is to test the hypothesis that dietary fiber will help modulate the gut environment and enhance immunity.
Further research is still going on to ascertain variations in fiber and their roles in helping patients with cancer (melanoma especially).

SOURCES:
1. https://www.nih.gov/news-events/nih-research-matters/fiber-diet-linked-cancer-immunotherapy-response
2. https://medicaldialogues.in/diet-nutrition/news/association-between-vitamin-d-and-type-2-diabetes-is-affected-by-magnesium-intake-study-finds-86270?infinitescroll=1
3. : Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response. Spencer CN, McQuade JL, Gopalakrishnan V, McCulloch JA, Vetizou M, Cogdill AP, Khan MAW, Zhang X, White MG, Peterson CB, Wong MC, Morad G, Rodgers T, Badger JH, Helmink BA, Andrews MC, Rodrigues RR, Morgun A, Kim YS, Roszik J, Hoffman KL, Zheng J, Zhou Y, Medik YB, Kahn LM, Johnson S, Hudgens CW, Wani K, Gaudreau PO, Harris AL, Jamal MA, Baruch EN, Perez-Guijarro E, Day CP, Merlino G, Pazdrak B, Lochmann BS, Szczepaniak-Sloane RA, Arora R, Anderson J, Zobniw CM, Posada E, Sirmans E, Simon J, Haydu LE, Burton EM, Wang L, Dang M, Clise-Dwyer K, Schneider S, Chapman T, Anang NAS, Duncan S, Toker J, Malke JC, Glitza IC, Amaria RN, Tawbi HA, Diab A, Wong MK, Patel SP, Woodman SE, Davies MA, Ross MI, Gershenwald JE, Lee JE, Hwu P, Jensen V, Samuels Y, Straussman R, Ajami NJ, Nelson KC, Nezi L, Petrosino JF, Futreal PA, Lazar AJ, Hu J, Jenq RR, Tetzlaff MT, Yan Y, Garrett WS, Huttenhower C, Sharma P, Watowich SS, Allison JP, Cohen L, Trinchieri G, Daniel CR, Wargo JA. Science. 2021 Dec 24;374(6575):1632-1640. doi: 10.1126/science.aaz7015. Epub 2021 Dec 23. PMID: 34941392.

Recently the FDA issued a report; which centered on the increasing use of antibiotics in pigs, chicken, cows and seafood between 2009 and 2013. Antibiotics are usually administered into the animals we eat and they are mostly given in low doses to promote faster growth or prevent diseases.

New research from New Zealand has found children given antibiotics in the first one to two years of their life may be at a greater risk of having a higher body-mass index (BMI) or becoming obese by the age of four or five.

Now, this action is a major concern for both the FDA and Centers for disease control and Prevention (CDC). They have claims that these constant use of antibiotics give rise to the multiplication of harmful bacteria due to bacteria resistant after long periods of abuse. But, apart from this concern, scientists are also searching to see if humans would also gain weight from the prolonged use of antibiotics as animals would.

HOW DO ANTIBIOTICS CHANGE A PERSON’S MICROBIOME?

Our intestinal microbiome is all the microorganisms in our digestive tract, and you have to look at it like a human organ, just as important as your heart, brain and lungs. Our digestive tract (gut) contains about over 100 trillion bacterial cells of many types. Usually, there is always an equilibrium of species; they help our bodies digest food and function well. Antibiotics change this gut flora, by creating a imbalance between good and bad bacteria.

How does this affect my weight?

Many types of bacteria in your gut affect how your body absorbs calories. Creating an imbalance of bacteria- especially the type that breaks food down into energy—you may be absorbing more calories from the same amount of food you eat than you would normally d because of this effect.
Research shows that obese people have a different mix of bacteria in their gut than lean people.
Most times though, it might not be direct contact with antibiotics but indirect contact from animals (food) that has been fed with antibiotics or even water treated with antibiotics.

Which foods have the most antibiotics in them?

Mostly animal products carry substantial amounts of antibiotics; and they are administered o them directly or added to their feeds if they would be commercialized.
Pigs have the most antibiotics in their meat, then chicken, then beef, according to research from the National Academy of Sciences. Also, farmed seafood like shrimp, fish (especially commercially farmed salmon) contain high levels of antibiotics because the drugs are needed to prevent disease in the farming pens. Even organic vegetables have antibiotics in them because about 75 percent of antibiotics fed to livestock are excreted out, and in the manure used to fertilize fields.

How can this be curbed?

The only real solution to this is if there is a strong rule stating that the use of antibiotics be stopped by farmers or food producers.

So, what can I do?

1. Reduce your intake of unprescribed antibiotics (that’s a good place to start at least).
2. Always look out for food labels stating about the use of antibiotics . visit supermarkets that sell whole foods and not processed or prepackaged foods.
3. Increase your intake of prebiotics and probiotics so your gut flora would be at equilibrium. Examples include yoghurt, kitchen, sauekrat,  fermented corn starch made into pudding (pap) etc.
4. Reduced intake of pork, farmed shrimps and sea foods.

Summary
Keep your gut healthy, do more of real foods and add as much sources of probiotics to your diet as you can. You should be in charge of your health.

Sources
1. https://www.google.com/search?q=gut+flora&rlz=1C1SQJL_enNG936NG936&oq=gut+flora&aqs=chrome..69i57j0i512l9.1898j0j7&sourceid=chrome&ie=UTF-8
2. http://a-healthy-body.com/are-antibiotics-making-us-fat/

3.https://www.google.com/amp/s/theconversation.com/amp/the-link-between-antibiotics-and-obesity-in-children-doesnt-mean-you-need-to-avoid-antibiotics-130392

The talk about gut health and hormones isn’t yet hitting the internet as it should. Rather, everyone is more concerned about their shape and the size of their belly. Your gut and hormones are intrinsically connected and affect your health in ways you can’t imagine.
This write up helps explain the link between your gut and hormones.

What Is The Estrobolome?
The estrobolome is a collection of bacteria in the gut which is capable of metabolising and modulating the body’s circulating estrogen. It is the bacteria in the gut, and the estrobolome, that affects estrogen levels, which in turn can impact weight, libido and mood. The estroblome modulates the enterohepatic circulation of estrogens and affects circulating and excreted estrogen levels.

Hormones And Gut Health: Why should I care about my Gut Health?
Scientific research has demonstrated that gut microbes regulate many aspects of human physiology, including intestinal permeability, the absorption of nutrients from food, and immunity.

Optimising our gut health is key to keeping our hormones in balance. Gut health is so important because the microbiome has many functions as listed below:
• Aids the synthesis and regulation of hormones and neurotransmitters
• Facilitates absorption of macro and micronutrients
• Has an essential role in the immune system
• Contributes to regulation of estrogen levels in the body
Estrogens are primarily made in the ovaries and adrenal glands. There are three different types, which are Estradiol, Estriol, and Estrone. All of which have vital roles in the body. In women, estrogens help regulate body fat, are essential to female reproductive function, cardiovascular health, bone health, and brain function (including memory). In men, estrogens aid in the maturation of sperm and maintenance of libido, oh yes! Male folks has estrogen too.
When the gut microbiome is healthy, the estrobolome is producing optimal levels of an enzyme called betaglucuronidase – there is an imbalance in estrogen when there is too much production of this enzyme.
Betaglucuronidase also has an important role in breaking down complex carbohydrates and the absorption of bilirubin and flavonoids. A healthy, diverse gut microbiome with a rich collection of different bacteria is critical for hormonal balance.
A healthy estrobolome minimises reabsorption of estrogen from the gut allowing safe removal as waste in stool and urine again ensuring hormone balance.
Gut dysbiosis is an imbalance of the gut bacteria in the gastrointestinal tract. Elevated betaglucuronidase levels are associated with conditions including:
• Pre-menstrual syndrome (PMS)
• Obesity
• Metabolic syndrome
• Estrogen-related cancers (breast and prostate)
• Endometriosis
• Infertility
• Mood swings (the feel good hormones are produced in the gut, if the gut is not healthy, it sends wrong signals)
• Heart disease
Unfortunately, gut dysbiosis and gut microbiome imbalance are very common and the delicate balance of the microbiome and estrobolome can be affected by many different factors which include genetics, age, weight, diet, alcohol, antibiotics, environmental pollutants and more.

Signs of an Unhealthy Gut
There are many signs of an unhealthy gut, which can often be misdiagnosed as something else.
• Digestive issues (bloating, gas, diarrhoea or constipation)
• Weight changes
• Food sensitivities
• Fatigue
• Skin irritation
• Autoimmune conditions
• Hormonal imbalance

Factors that affect Gut Health And Hormone Balance
To correct hormone imbalance, there are ways to ensure that the gut stays healthy and those ways include:
1. Dietary considerations
“The food we eat not only feeds our cells, but also determines what kind of inner garden we are growing in our guts.” – Dr. Mark Hyman.
Well, the saying “you are what you eat” comes to limelight here. Diet plays a vital role in shaping our gut microbiome. A low GI (glycaemic index) diet which contains a diverse range of fruit, vegetables and fibre, high in phytonutrients – the so-called ‘rainbow plate’ – can encourage microbial diversity.
It is important to go moderate on what is referred to as ‘white carbs’ such as pasta, rice and potatoes which contain resistant starch; a type that promotes healthy gut. Cutting them out totally would mean cutting out the sources of resistant starch.
Bear in mind that cruciferous vegetables, such as broccoli, contain compounds that ease detoxification of estrogen. The supplement DIM (diindolylmethane) contains concentrates of such compounds and can be effective in lowering more toxic estrogen byproducts.
Prebiotics and probiotics should also be considered. Prebiotic foods such as garlic, onion, asparagus and bananas provide the material that gut bacteria like to feed on. Probiotic foods such as kefir, kombucha, kimchi, plain yoghurt and other fermented foods are really useful for introducing beneficial bacterial strains, like lactobacillus, to the gut.
It’s important to note that the supplement calcium D glucarate is a betaglucuronidase inhibitor and allows estrogen to remain conjugated, and therefore safely eliminated by intestinal detoxification.
2. Your environment matters a lot
Phytoestrogens from plants such as soya, tofu and tempeh are consumed as food while others are synthetically manufactured and called Xenoestrogens. These are found in common household products such as fragrances, pesticides and plastics, and can easily be obtained from the environment around us. It is important to find ways of reducing these toxic substances that impact our health and find more environmentally friendly solutions. Xenoestrogens are absorbed by the body and stored in liver and fat cells. They act synergistically with endogenously produced estrogens and influence cell proliferation and disrupt the delicate balance of hormones.
3. Antibiotics
So many people abuse antibiotics, if not prescribed, please desist from using them. The use of antibiotics disrupts the ecology of the gut microbiome, and can cause overgrowth or dysbiosis. A study by the University of Copenhagen found that six months after stopping antibiotics, most healthy people can recover the microbiome composition and function. However, the gut can still lack some of the beneficial bacteria and we then need to reintroduce the good guys!
4. Alcohol
No one really wants to hear that overconsumption of alcohol is detrimental to the health. Our society has made it look like consuming alcohol doesn’t make you vulnerable at all. But alcohol consumption can have a negative impact, not only on the gut microbiome but also on the liver and its ability to detoxify. This contributes to estrogen dominance symptoms and an increased risk of estrogen related cancers. Its festive season and you must unwind with friends and families, so we won’t put a knife to your throat not to take alcohol. 1 drink a day for women and 2 drinks a day for men( 1 drink equates 12 ounces of beer, 8 ounces of malt liquor, 5 ounces of wine, 1.5 ounces of distilled spirits and liquor). A single large glass of wine can contain up to 3 units of alcohol!
5. Physical activity
Physical activity can never be overemphasised. Exercise is an excellent way to support the detoxification that happens in the liver. Regular, moderate intensity exercise can lower levels of circulating estrogens. It can also reduce the stress hormone, cortisol, which can have a negative impact on our sex hormones. However, we do need to be mindful of individuality as different people have different stress levels/thresholds. Activities that stimulate the parasympathetic nervous system or the body’s ‘rest and digest’ mode, such as yoga, are also very beneficial to hormonal health and keeps the hormones balanced.
Summary
Lifestyle, nutrition, physical activity and stress management all play important roles in helping to balance your estrobolome and also ensuring that we keep our hormones balanced and optimal.

There seems to be a lot of debate out there about artificial sweetners.

Some research says its good for weightloss and as a good substitute for table sugars, while some say it would increase the risk of  cancer and also increase blood sugar level.

Well, lets dive into this troubled waters and see what we can pull out of it shall we?

 

What Are Artificial Sweeteners?

Artificial sweeteners, or sugar substitutes, are chemicals added to some foods and beverages to make them taste sweet.

They tend to provide a taste that seems 1,000 times sweeter than regular sugar.

Although some sweeteners contain calories, the amount needed to sweeten products is so small that you end up consuming almost no calories.

They are mostly used in beverages and drinks since they provide zero calories.

 

How Do Artificial Sweeteners Work?

The surface of your tongue is covered by many taste buds. Each taste bud contains several taste receptors that detect different flavors ( sweet, sour, salty).

Each time you eat, the different food molecules contact your taste receptors.

When the food molecule meets with the receptor, it (receptor) sends a signal to your brain, allowing you to identify the taste

For example, the sugar molecule fits perfectly into the taste receptor for sweetness, like a missing pixzle piece  allowing your brain to identify the sweet taste.

The molecules of artificial sweeteners are similar enough to sugar molecules that they fit on the sweetness receptor.

However, they are generally too different from sugar for your body to break them down into calories. This is why they have a sweet taste without the added calories.

Only a minority of artificial sweeteners have a structure that your body can break down into calories. Because only very small amounts of artificial sweeteners are needed to make foods taste sweet, you consume virtually no calories.

Reason why they won’t provide calories (energy) is because your body cannot break them down.

What Are the Names of Artificial Sweeteners?

The following artificial sweeteners are allowed for use in the US and/or the European Union:

Aspartame: 200 times sweeter than table sugar. Aspartame is known under the brand names Nutrasweet, Equal or Sugar Twin.

Acesulfame potassium: 200 times sweeter than table sugar. Acesulfame potassium is suited for cooking and baking and known under brand names Sunnet or Sweet One.

Advantame: 20,000 times sweeter than table sugar, suited for cooking and baking.

Aspartame-acesulfame salt: 350 times sweeter than table sugar, and known under the brand name Twinsweet.

Cyclamate: 50 times sweeter than table sugar. Cyclamate is suited for cooking and baking. However, it’s been banned in the US since 1970.

Neotame: 13,000 times sweeter than table sugar. Neotame is suited for cooking and baking and known under the brand name Newtame.

Neohesperidin: 340 times sweeter than table sugar. It is suited for cooking, baking and mixing with acidic foods. It is not approved for use in the US.

Saccharin: 700 times sweeter than table sugar. It’s known under the brand names Sweet’N Low, Sweet Twin or Necta Sweet.

Sucralose: 600 times sweeter table sugar. Sucralose is suited for cooking, baking and mixing with acidic foods. It’s known under the brand name Splenda.

There’s also a new guy om the block called ‘allulose’ made from grains.

Effects on Appetite

Some people believe artificial sweeteners might actually increase appetite and promote weight gain .

Because they taste sweet but lack the calories found in other sweet-tasting foods, they’re thought to confuse the brain into still feeling hungry after consumption.

Additionally, some scientists think you’d need to eat more of an artificially sweetened food, compared to the sugar-sweetened version, in order to feel full; well, who knows?

Although these theories are plausible, there’s mo back up claim whatsoever to them.

Effect on weight

Well, we have seen that artificial sweetners do not contain calories at all, so obvioulsy they wont increase your risk of gaining extra pounds.

But once they increase your sugar cravings, its better you stick to water than that can of soda.

 

Effects on diabetes

Artificial sweetners would reduce your intake of refined sugar, thereby making it easy for your insulin levels to work. It doesnt have any adverse effects on your glucose yes, but it is better you seek advice from your dietitan or doctor before using them.

Effect on gut health

The health of your gut totally determines if you would be vulnerable to certain illness.

Once your gut is not happy with you, you are at risk of poor blood sugar control,  weakened immune system, and disrupted sleep.

Some studies suggest that selected sweetners could disrupt the health of your gut by affecting the balance of gut bacteria.

Artificial sweetners and cancer

Apart from cyclamate which was banned in 1970 in America, no other other study has linked artificial sweetners with cancer.

 

Artificial sweetners and Dental health

Unlike sugars, artificial sweetners do not react with bacteria in your mourh to form acids. So, they dont affect your dental health negatively.

1. Some sweetners could cause headaches, seizures or depression in some individuals while leaving out others.

 

Safety and side effects

Artificial sweetners are safe to use but should not be consumed by individuals with phenylketonuria or those allergic to sulfonamides.

 

Take home Message for all

The use of artificial sweetners pose no threats to the health if used as alternatives to sugars.

Some risks attatched to it might be severe or different in individuals, so its best  to seek advice before selecting a sweetner.

Source: https://www.healthline.com/nutrition/artificial-sweeteners-good-or-bad#section12