cholesterol

Globally, deaths arising from raised cholesterol levels reads at 2.6 million and this is sad. What’s sadder is the fact that about 10% of these people didn’t realize they have it; even the ones still alive.

Cholesterol might either be termed good or bad and many factors can influence the levels of cholesterol in your blood especially genetics.

Apart from lifestyle, diet and exercise, genetics could be a risk factor for increased cholesterol levels. If a family member has high cholesterol levels, there is every tendency you might have it especially if you don’t pay attention to lifestyle matters.

This phenomenon is termed “familial” since it runs in a family.

SOME FACTS ABOUT FAMILIAL HYPERCHOLESTEROLAEMIA

– 1 person in every 500 persons has it

– Doesn’t have symptoms, but these signs like deposits of cholesterol in skin and tendons could be notice

– Only 10%-20% of people with it know they have it

– Individuals with familial hypercholesterolaemia will pass it on to their children

IS THERE A DIFFERENCE BETWEEN FAMILIAL HYPERCHOLESTEROLAEMIA AND NORMAL HYPERCHOLESTEROLAEMIA?

If high levels of cholesterol occur in any relative of yours, such as a parent, sibling, or grandparent, you’re more likely to have it yourself. This occurrence is totally due to the passing on of genes from parents to children that increase levels of cholesterol in the blood.

Familial hypercholesterolaemia is more like an inherited form of hypercholesterolaemia. People with this type of conditions normally would have high cholesterol levels even with a lifestyle modification. Simply because they don’t have the capacity to regulate their cholesterol levels as other individuals.

There is every tendency that people with familial hypercholesterolaemia might not be able to control their cholesterol levels with just diet and exercise alone, but with medications too.

You should also note that not everyone with a high risk of developing high cholesterol actually has their cholesterol levels sky rocketing.

HOW DO I KNOW IF I HAVE FAMILIAL HYPERCHOLESTEROLAEMIA

One of the major ways to ascertain if you have high cholesterol levels especially if it’s a familial case is through a lipid screening test. This measures the amount of cholesterol in your blood.

Ideally, signs to look out for in adults are cholesterol levels above 190mg/dl and levels above 160mg/dl in children.

In addition, your doctor might help detect physical signs, which might not be common to everyone. These signs includes:

– Bumps or lumps around your knees, knuckles, or elbows

– Swollen or painful Achilles tendon

– Yellowish areas around your eyes

– A whitish grey colour in the shape of a half-moon on the outside of your cornea

WHAT CAUSES FAMILIAL HYPERCHOLESTEROLAEMIA?

This type of cholesterolaemia is a genetic one meaning it is hereditary and is caused by a defect on chromosome 19.

Your body finds it difficult to remove LDL cholesterol from the body making it easy for the narrowing of vessels which might possibly lead to atherosclerosis. You just need to get an abnormal gene from one family member to get this disease.

WHAT ARE THE RISK FACTORS AND HOW DO I MANAGE THEM?

1. OBESITY OR HIGH WAIST CIRCUMFERENCE: Both obesity and a high waist circumference can increase your risk for high cholesterol.

Obesity is defined as a body mass index (BMI) of 30 or higher, while a high waist circumference is 40 or more inches for men and 35 or more inches for women.

If you have a family history of hypercholesterolaemia, then you should be careful so fat wont be unevenly distributed in your body. When fat accumulates in only one part of the body, especially in the abdominal region, it can lead to an increased risk of developing hypercholesterolaemia and other cardiovascular complications.

2. ELEVATED BLOOD SUGAR

As someone with a family history of hypercholesterolaemia, you should also be aware of your glucose levels as high levels of glucose can increase LDL cholesterol and decrease HDL cholesterol, damage the lining of arteries and also increase your risk of fatty deposits building up in your arteries.

Lifestyle choices, like diets high in soda, candy, or other foods containing large amounts of sugar, can also contribute to high blood sugar levels.

Reducing your intake of these things that contribute to an increased glucose level is key to reducing the risks of high cholesterol levels. An increased fibre intake of at least 30-35g of fibre daily would help to keep glucose levels in check.

3. LIFESTYLE FACTORS

If you have a family history of high cholesterol, you should consider some modifications to your lifestyle as it totally affects your chances to also get the disease. Diet, exercise and social vices are risk factors associated with high cholesterol. They can be controlled by modifying your lifestyle.

– Eating a diet high in saturated and trans fats can increase your cholesterol levels. These highlighted foods should be taken away from your diet totally or restricted to the barest minimum if you have a history of high cholesterol in the family.

• red meat

• full-fat milk and yogurt

• fried foods

• highly processed sweets

More so, adding foods that are cholesterol reducing would help reduce the risks of developing high cholesterol. Foods like nuts, beans, whole grains, fruits, vegetables, green vegetables, lentils, oatmeal, whole grain breads, low-fat dairy, low-fat meats, such as poultry are helpful.

– Exercise has the tendency to help increase your HDL cholesterol and decrease your LDL cholesterol. If you can aim at 150 minutes of moderate to intense aerobic exercise weekly, then you’re on journey to increasing you HDL levels which helps to reduce risk for developing high cholesterol and other coronary diseases.

If you just want to start, you can try out walking a distance first before doing other types of exercise so as not to get fagged out easily.

– Tobacco Smoking damages the wall of your blood vessels and is detrimental to your heart health. This makes it more likely for fat deposits to build up, thereby increasing your risk of high cholesterol levels.

CONCLUSION

Apart from other risk factors, genetics is a major risk factor related to high cholesterol levels. It is very important to be aware of this condition especially if it runs in your family and also aware of measures to curb its progression.

SOURCES

1. https://www.healthline.com/health/high-cholesterol/is-high-cholesterol-hereditary#outlook

2. https://www.health.harvard.edu/heart-health/when-very-high-cholesterol-runs-in-the-family-

3. https://medlineplus.gov/ency/article/000392.htm#:~:text=Familial%20hypercholesterolemia%20is%20a%20genetic,of%20LDL%20in%20the%20blood.

4. https://www.cdc.gov/cholesterol/facts.htm

 

 

 

 

 

 

OVERVIEW

Arteriosclerosis occurs when the blood vessels that carry oxygen and nutrients from your heart to the rest of your body (arteries) become thick and stiff — sometimes restricting blood flow to your organs and tissues. Healthy arteries are flexible and elastic, but over time, the walls in your arteries can harden, a condition commonly called hardening of the arteries.

Atherosclerosis is a specific type of arteriosclerosis, but the terms are sometimes used interchangeably. Atherosclerosis refers to the buildup of fats, cholesterol and other substances in and on your artery walls (plaque), which can restrict blood flow.

This plaque makes your arteries clogged up and could lead to other heart diseases. 

The plaque can burst, triggering a blood clot. Although atherosclerosis is often considered a heart problem, it can affect arteries anywhere in your body. Atherosclerosis may be preventable and is treatable.

 

SYMPTOMS

Atherosclerosis develops gradually. Mild atherosclerosis usually doesn’t have any symptoms.

You usually won’t have atherosclerosis symptoms until an artery is so narrowed or clogged that it can’t supply adequate blood to your organs and tissues. Sometimes a blood clot completely blocks blood flow, or even breaks apart and can trigger a heart attack or stroke.

Symptoms of moderate to severe atherosclerosis depend on which arteries are affected. For example:

 

• HeartArteries: chest pain or pressure (angina).
• BRAIN:sudden numbness or weakness in your arms or legs, difficulty speaking or slurred speech, temporary loss of vision in one eye, or drooping muscles in your face. These signal a transient ischemic attack (TIA), which, if left untreated, may progress to a stroke.
• ARMS AND LEGS:symptoms of peripheral artery disease, such as leg pain when walking (claudication).
• KIDNEYS: you develop high blood pressure or kidney failure.

Early diagnosis and treatment can stop atherosclerosis from worsening and prevent a heart attack, stroke or another medical emergency.

CAUSES

Atherosclerosis is a slow, progressive disease that may begin as early as childhood. Although the exact cause is unknown, but it may start with damage or injury to the inner layer of an artery. The damage may be caused by:

1. High blood pressure
2. High cholesterol
3. High triglycerides, a type of fat (lipid) in your blood
4. Smoking and other sources of tobacco
5. Insulin resistance, obesity or diabetes
6. Inflammation from diseases, such as arthritis, lupus or infections, or inflammation of unknown cause

Once the inner wall of an artery is damaged, blood cells and other substances often clump at the injury site and build up in the inner lining of the artery.

Over time, fatty deposits (plaque) made of cholesterol and other cellular products also build up at the injury site and harden, narrowing your arteries. The organs and tissues connected to the blocked arteries then don’t receive enough blood to function properly.

Eventually, pieces of the fatty deposits may break off and enter your bloodstream.

In addition, the smooth lining of the plaque may rupture, spilling cholesterol and other substances into your bloodstream. This may cause a blood clot, which can block the blood flow to a specific part of your body, such as occurs when blocked blood flow to your heart causes a heart attack. A blood clot can also travel to other parts of your body, blocking flow to another organ.

 

RISK FACTORS

Hardening of the arteries occurs over time. Besides aging, factors that increase the risk of atherosclerosis include:

• High blood pressure
• High cholesterol
• Diabetes
• Obesity
• Smoking and other tobacco use
• A family history of early heart disease
• Lack of exercise
• An unhealthy diet

COMPLICATIONS 

The complications of atherosclerosis depend on which arteries are blocked. For example:

1. Coronary artery disease- When atherosclerosis narrows the arteries close to your heart, you may develop coronary artery disease, which can cause chest pain (angina), a heart attack or heart failure.
2. Carotid artery disease. When atherosclerosis narrows the arteries close to your brain, you may develop carotid artery disease, which can cause a transient ischemic attack (TIA) or stroke.
3. Peripheral artery disease. When atherosclerosis narrows the arteries in your arms or legs, you may develop circulation problems in your arms and legs called peripheral artery disease. This can make you less sensitive to heat and cold, increasing your risk of burns or frostbite. In rare cases, poor circulation in your arms or legs can cause tissue death (gangrene).
4. Aneurysms. Atherosclerosis can also cause aneurysms, a serious complication that can occur anywhere in your body. An aneurysm is a bulge in the wall of your artery.

 

Most people with aneurysms have no symptoms. Pain and throbbing in the area of an aneurysm may occur and is a medical emergency.

        5. Chronic kidney disease. Atherosclerosis can cause the arteries leading to your kidneys to narrow, preventing oxygenated blood from reaching them. Over time, this can affect your kidney function, keeping waste from exiting your body.

 

PREVENTION

A healthy lifestyle modification targeted at tackling the symptoms or even keeping them away would help prevent atherosclerosis. Lifestyle changes like these would help:

Quitting smoking (cannabis, cigarettes)

Eating healthy foods and keeping away from saturated fats, trans fats and highly processed foods.

Exercising regularly

Maintaining a healthy weight

Adopt lifestyle changes that are manageable by you on a long run.

 

Sources: https://www.mayoclinic.org/diseases-conditions/arteriosclerosis-atherosclerosis/symptoms-causes/syc-20350569

 

Fenugreek is truly an amazing plant with so many health benefits. People from Western Asia and the Mediterranean have used fenugreek for thousands of years to improve the flavour of their food, improve health, and soothe skin maladies. In more recent times, this herb has supposedly gained global popularity as a herbal supplement with a variety of health benefits.

While fenugreek has many promising applications/ benefits, not all of its uses have yet been backed up by rigorous scientific examination. This tour will tell us which of fenugreek’s health benefits are supported by evidence, and which ones remain more assumptions and advertising gimmicks than fact.

Let’s take a dive together to learn what fenugreek is, what it does in the body, and how best to utilize all its

benefits. Shall we?

What Is Fenugreek?

Fenugreek (scientific name Trigonella foenum-graecum) is a plant native to Western Asia and the Mediterranean. It has three green or yellow oblong leaves, which can be consumed fresh or dried.

Fenugreek leaves and seeds are important for cooking and medicines. Because of their sweet, maple-syrup like smell and flavour, fenugreek seeds are also added to artificial maple syrup, candies, ice cream, beverages, tobacco, soaps, and cosmetics.

 

 

What Makes Fenugreek Work? Important Compounds

Well, as stated below, the health benefits of fenugreek involve the regulation of blood sugar, stimulation of milk flow in new mothers, maintenance of hormones, and treatment of inflammation; made possible by the presence of the outlined compounds:

• Trigonelline: a betaine molecule also present in coffee and alfalfa that may help prevent and treat diabetes.

• 4-hydroxyisoleucine and 2-oxoglutarate: molecules with an insulin-stimulating effect.
• Protodioscin: compound that may have aphrodisiac effects.
• Diosgenin and Yamogenin: compounds used in the commercial synthesis of progesterone and other steroid products.
• 3-Hydroxy-4,5-dimethyl-2(5H)-furanone: compound that causes a maple-syrup scent in body excretions.

Now that we’ve taken a look at what fenugreek does, let’s appreciate its functions.

Look before you leap! Some retailers care more about their pockets than your health. (Shine your eyes)

 

Why You Should Be Cautious About Herbal Supplements

Herbal remedies can be very effective alternative treatments to prescription medication. At the same time, there’s a big business of retailers that exaggerate health claims to market their products and make money.

The best way to evaluate these claims is to take a look at objective, rigorous scientific research. Has the supplement been tested in a randomized control trial and been proven to have statistically significant effects? Has it been used on human subjects and not just lab mice? If its benefits are purely anecdotal, then you might not want to waste your time or money, or worst case scenario, risk causing yourself more harm than good.

With these guiding principles in mind, we’ve done a thorough research on fenugreek, its uses, contraindications and special cases.

Fenugreek Benefits: Analysis of 4 Popular Uses

People take fenugreek in a variety of forms as an herbal supplement. Its most common form is a pill or capsule, but it can also be made into a tea or ground up and combined with other ingredients to make a poultice and applied to injured skin.

The most commonly claimed fenugreek benefits are milk production in new mothers, blood sugar levels, testosterone and male libido, and treating inflammation.

Fenugreek can act as a galactagogue.

 

Use 1: To Enhance Milk Production in New Mothers

Fenugreek is widely used as a galactagogue, or a milk flow-enhancing agent in new mothers. Nursing women take fenugreek in pill form or drink it as a tea after they’ve had a baby.

While fenugreek appears to be an effective galactagogue, it can have adverse effects if you take it while pregnant. Most doctors advise that women should only take fenugreek supplements once they’ve had their baby and not before.

Scientists believes it contains phytoestrogens, which are plant chemicals similar to the female sex organs oestrogen. They really don’t know how it happens though, they only believe breasts are modified sweat glands, and fenugreek promotes sweat production.

The plant has aggravated asthma symptoms in women and caused low blood glucose in diabetics; it should not be used by all.

Since its evidence backed that fenugreek could be used as a milk-enhancing agent, how should you take it?

 

 

How to Take Fenugreek to Stimulate Milk Production

Its best to speak to your doctor/ dietitian before taking fenugreek as it could have significant side effects during pregnancy. I remember one woman complaining to me how it makes her add more weight.

If you decide to take fenugreek, you could take it as fenugreek tablets or drink it as a fenugreek tea. A typical dosage is two to three capsules (580 to 610 mg each) taken by mouth three times a day. Drinking it as a tea is a milder amount. You might drink between 1-3 cups a day as a hot tea, iced tea, or mixed with apple juice.

 

Use 2: To Maintain Blood Sugar Levels

Fenugreek seeds are commonly used as a supplement to control blood glucose, especially to prevent or treat diabetes. It appears to alleviate problems around the metabolism of blood sugar.The seed contains fibre and other possible compounds that could slow digestion and the body’s absorption of carbohydrates and sugars.

How to Take Fenugreek to Control Blood Glucose

The most common ways to take fenugreek to control blood sugar levels are in capsule form, ground up and added to food, or made into a tea. The recommended dosage falls between 2.5 and 15 grams a day. The amount you take varies depending on your weight, any other medications you take, and other factors.

It would be really unwise to just depend solely on fenugreek to help in the treatment of diabetes; speak to your dietitan and doctor for possible and sustainable ways to handle your diabetes.

 

Use 3: To Boost Libido

One of fenugreek’s ancient uses is to enhance libido. Mediterranean and Western Asian cultures have incorporated the herb into their diets for thousands of years to enhance sexual desire. Recent studies have suggested that fenugreek may increase libido in both men and women.

Well, research holds that it’s a better aphrodisiac than banana, asparagus and almonds.

Ultimately, researchers concluded that “T foenum-graecum [fenugreek] seed extract is a well-tolerated and an effective botanical medicine for use in the support of sexual function for pre-menopausal women, in particular increasing sexual desire and arousal, with positive effects in concentration of E2 [estradiol] and free testosterone.” The studies suggest that fenugreek supplements may increase libido in both men and women.

How to Take Fenugreek to Boost Libido

Fenugreek can be taken as a capsule or brewed into a tea, or the seeds can be ground up and added to food or bread. A dose of 500 to 600 mg fenugreek capsules per day is recommended to boost libido. As with any herbal supplement, you should check with your doctor to determine the right amount for you.

 

Is your skin red, bumpy, or injured? A fenugreek-based poultice can help.

 

Use 4: To Soothe Skin Inflammation or Injury

Fenugreek powder has long been combined with other soothing herbs to make poultices and treat skin inflammation and injury. Recent studies have suggested that fenugreek may have anti-inflammatory and antioxidant properties.

How to Use Fenugreek to Treat Skin Inflammation

To soothe injured or inflamed skin, people traditionally grind dried herbs or boil fresh herbs in water and make a paste. You might combine fenugreek seed powder with other skin-soothing herbs, like slippery elm, flaxseed, as well as medicinal charcoal. After combining everything into a paste, just spread it across a clean piece of gauze, linen, or cotton and apply it directly to the skin.

Leave the poultice on the affected area for about 1 to 24 hours, taking it off when the skin feels better.

Along with the four main uses described above – enhancing milk production, controlling blood glucose, boosting libido, and treating skin inflammation – people claim a number of other fenugreek health benefits. Let’s take a look at other potential positive effects of taking fenugreek; with little scientific back up though.

Other Potential Health Benefits of Fenugreek (anecdotal)

People have been consuming fenugreek for thousands of years, and many believe that it has a wide range of physical benefits. These are a few additional anecdotal fenugreek seeds benefits:

• Balance cholesterol
• Soothe upset stomach and digestive problems
• Reduce menstrual cramps
• Reduce appetite
• Control obesity
• Maintain liver and kidney health (hepatic and renal issues)
• Soothe muscle pain
• Reduce fever

At this point, there’s little scientific evidence behind these alleged benefits, so much more research is needed to assess the efficacy of this herbal supplement.

Apart from having health benefits, Fenugreek also has some potential adverse side effects, and it’s important to be aware of them before incorporating the supplement into your routine because physiology differs.

Fenugreek Side Effects: 6 Potential Problems

‘They are just supplements (herbal at that), they should not pose any threat; calm down first.

The following are the six main potential fenugreek side effects.

 

Side Effect 1. Induce Childbirth

For the most part, pregnant women are advised not to take fenugreek. Because it contains oxytocin, fenugreek could act as a uterine stimulant, meaning it could cause contractions and preterm labour. Some people have used fenugreek to induce labour, don’t try this at home.

The other side effect of taking fenugreek while pregnant is that it can give a false alarm of Maple Syrup Urine Disease (MSUD). MSUD is an inherited genetic disorder so named because it causes a maple syrup-like smell in body excretions (urine).

 

Side Effect 2. Diarrhoea

Fenugreek may cause stomach irritation and diarrhea. Excessive intake in pregnancy could lead to episodes of diarrhoea, gastrointestinal disturbances as nausea, vomiting and flatulence could also occur.

Side Effect 3. Bleeding

Fenugreek contains a chemical compound called coumarin that can act as a blood thinner. People on blood-thinning or anti-coagulant medications to be careful and consult their doctors before taking fenugreek supplements.

 

Be careful if you take a blood thinner, as fenugreek could cause excessive bleeding.

Side Effect 4. Hypoglycemia

If you’re taking both medicine for diabetes and fenugreek supplements, you should measure your blood sugar levels so they don’t become too low and cause hypoglycemia. Since fenugreek can lower blood glucose levels, its best you are always alert about your glucose levels.

Consult with your doctor about the right amount, and carefully monitor the effects that fenugreek supplements have on your blood sugar levels.

 

Side Effect 5. Allergic Reactions

Before introducing new things to your, you should be conscious of the possible allergic effects attached to that food.

Check with your doctor, and try just a small dosage of fenugreek at first. Stop taking it if you experience a rash, hives, swelling, or trouble breathing.

 

Side Effect 6. “Maple Syrup” Sweat or Urine

This last side effect doesn’t cause any harm, apart from the false alarm about MSUD in infants described above. Fenugreek has a strong, sweet odour, and eating the seeds might pass that maple syrup-like smell into your sweat and urine or the sweat and urine of a nursing baby. If you start to notice this maple syrup-like odour, then you’ll know the cause and what to do.

 

How to Take Fenugreek

Either in tea, pill, tincture or powder form, dosages should not exceed the under listed:

• Capsule: 500 to 600 mg, three times a day.
• Tea: two to three cups a day. You can make hot or iced tea or combine it with juice.
• Powder: five to 30 grams of de-fatted seed powder up to three times a day. It’s best to consume fenugreek powder before or as part of a meal.
• Tincture: three to four mL three times a day. One drop is similar to a 500-600 mg capsule.

Your dosage depends on a number of factors, including weight, age, and health status.

 

SUMMARY

Every seed, herb or fruit has potential health benefits attached to them if used in appropriate amounts, but when abused or used by the wrong groups, they could pose great health threats.

While adding fenugreek to your diet, remember its health benefits and also remember its contraindications and remember too that some presumed back up don’t have sufficient scientific claims.

SOURCE: blog.prepsholar.com/fenugreek-benefits-side-effects

ncbi.nlm.nih.gov/m/pubmed/3000083/

www.washingtonpost.com/blogs/blogspot/post/fenugreek-can-increase-male-libido/2011/06/20/AG0xpqcH_blog.html