Cancer

Cancer has been a threat globally and every professional has been on their toes to proffer a solution.
Immunotherapy, therefore, is one of the ways to help manage cancer patients
Immunotherapy involves stimulation of the immune system to help fight cancer. This method has shown tremendous improvements in the treatment of many tumors.

Even with this development, there are individual responses to the treatment. For some people, the tumors might shrink or disappear totally, and for some, no effects at all.

Further research has gone into this case, and it has been noticed that the gut microbiome might have a role to play in the efficacy of immunotherapy. So, therefore, modifying the gut bacterium may help improve tumor response to immunotherapy.

FIBER INTAKE AND MELANOMA RISK

According to a study, a higher intake of dietary fiber (responsible for the promotion of healthy gut) was associated with improved response to immunotherapy, and in preclinical models, dietary fiber manipulation impacted antitumor immunity. According to Jennifer McQuade, MD, assistant professor of melanoma medical oncology at The University of Texas MD Anderson Cancer Center, “The dietary pattern associated with response to immunotherapy is the same diet recommended by American Cancer Society and American Institute for Cancer Research, which includes a diet rich in fruits and vegetables, whole grains and legumes. This diet is also recommended for secondary cancer prevention and prevention of cardiovascular disease and health in general.”
Furthermore, research has it that every 5% increase in fiber intake resulted in a 30% reduced risk of cancer progression or death.

RATIONALE
Previous research has shown gut microbes may regulate response to drugs that block protein (T-cells) checkpoints. Extensive studies on the effect of diet and probiotic supplements on patients with melanoma using drugs that inhibit these proteins are needed.

METHODOLOGY
McQuade and colleagues conducted a randomized prospective clinical trial to assess how varying fiber intake affects the gut microbiome and immune response among 128 patients with advanced melanoma receiving treatment with immune checkpoint inhibitors.

Researchers examined fecal microbiota profiles, dietary habits, and commercially available probiotic supplement use, and performed parallel preclinical studies.

KEY FINDINGS
According to a randomized prospective clinical trial to assess how varying fiber intake affects the gut microbiome and immune response among 123 patients with advanced melanoma, Patients who reported higher consumption of dietary fiber intake from fruits, vegetables, legumes, and whole grains experienced significantly longer PFS. Median PFS was not reached among the 37 patients with sufficient fiber intake, compared with median PFS of 13 months among the 91 patients with insufficient fiber intake.
After this, it was noticed that 82% of patients with both sufficient fiber intake and no probiotic use responded well to immunotherapy, compared with only 59% of patients who reported either insufficient fiber intake or probiotic use.
Probiotic supplement use alone did not appear associated with a significant difference, in short, data suggests it reduces chances of survival.

IMPLICATIONS
Based on these findings, oncologists, dietitians, and all others managing cancer patients, it is important to focus on how much fiber is consumed in their diet.
The aim is to test the hypothesis that dietary fiber will help modulate the gut environment and enhance immunity.
Further research is still going on to ascertain variations in fiber and their roles in helping patients with cancer (melanoma especially).

SOURCES:
1. https://www.nih.gov/news-events/nih-research-matters/fiber-diet-linked-cancer-immunotherapy-response
2. https://medicaldialogues.in/diet-nutrition/news/association-between-vitamin-d-and-type-2-diabetes-is-affected-by-magnesium-intake-study-finds-86270?infinitescroll=1
3. : Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response. Spencer CN, McQuade JL, Gopalakrishnan V, McCulloch JA, Vetizou M, Cogdill AP, Khan MAW, Zhang X, White MG, Peterson CB, Wong MC, Morad G, Rodgers T, Badger JH, Helmink BA, Andrews MC, Rodrigues RR, Morgun A, Kim YS, Roszik J, Hoffman KL, Zheng J, Zhou Y, Medik YB, Kahn LM, Johnson S, Hudgens CW, Wani K, Gaudreau PO, Harris AL, Jamal MA, Baruch EN, Perez-Guijarro E, Day CP, Merlino G, Pazdrak B, Lochmann BS, Szczepaniak-Sloane RA, Arora R, Anderson J, Zobniw CM, Posada E, Sirmans E, Simon J, Haydu LE, Burton EM, Wang L, Dang M, Clise-Dwyer K, Schneider S, Chapman T, Anang NAS, Duncan S, Toker J, Malke JC, Glitza IC, Amaria RN, Tawbi HA, Diab A, Wong MK, Patel SP, Woodman SE, Davies MA, Ross MI, Gershenwald JE, Lee JE, Hwu P, Jensen V, Samuels Y, Straussman R, Ajami NJ, Nelson KC, Nezi L, Petrosino JF, Futreal PA, Lazar AJ, Hu J, Jenq RR, Tetzlaff MT, Yan Y, Garrett WS, Huttenhower C, Sharma P, Watowich SS, Allison JP, Cohen L, Trinchieri G, Daniel CR, Wargo JA. Science. 2021 Dec 24;374(6575):1632-1640. doi: 10.1126/science.aaz7015. Epub 2021 Dec 23. PMID: 34941392.

The link between cancer and your diet is as mysterious as the genesis of the disease and how it spreads. So many research work has pointed to how nutrients may help prevent or conversely, lead to cancer.
While there are many factors you can’t change that increase your cancer risk, such as genetics and environment, there are others you can control.
According to the statement above, we’ll discuss so risk factors and importance of nutrients and how they could prevent cancer or lead to it.

CALCIUM
Some evidence suggests higher calcium intake can lower the risk for cancer, especially colorectal cancer. Researchers believe calcium binds to bile acids and fatty acids in the gastrointestinal tract. This acts as a shield to protect cells from the damaging stomach acids.
However, other research has shown that extra calcium—2,000 milligrams (mg) or more per day—may be linked to a higher risk of prostate cancer.

EXCESS CONSUMPTION OF ENERGY (CALORIES)
Excess consumption of calories without matching amount of physical activity would lead to an overload of unused energy thereby leading to obesity.
It was estimated in a recent study, from a prospective cancer prevention cohort, that overweight and obesity accounted for 14 percent of all cancer deaths in men and 20 percent of those in women. Significant positive associations were found between obesity and higher death rates for the following cancers: esophagus, colon and rectum, liver, gallbladder, pancreas, kidney, stomach (in men), prostate, breast, uterus, cervix, and ovary.

GLUCOSE METABOLISM
Refined sugar which is a high energy, low nutrient density foods is commonly present in foods termed ‘junks’. This also has been associated with different types of cancers especially colo-rectal cancer.

LOW FIBRE
A diet void of unrefined plant foods would be low in fiber. This type of diet has been linked to high risks of rectal cancer.

ALCOHOL INTAKE
Alcohol is an antagonist of folate. Folate is a B vitamin which helps in DNA synthesis. Over consumption of alcohol leads to low levels of folate in both men and women and this could lead to colon cancer in men and cervical cancer in women.

ANTIOXIDANTS
These are available to help prevent free radicals that damage cells within the body. Its important to consume a variety of fruits and vegetables as they contain different types of antioxidants.

PROCESSED RED MEAT
Processed meat is any meat that has been smoked or fermented or includes added salt and nitrites to enhance flavor. The mechanism is not yet known but the connection between cancer and processed red meat is consistent.
The reaction between nitrites and heme-iron in red meat might just lead to cell mutations.

PROBIOTICS
Probiotics are friendly bacteria contained in foods like yoghurt, kefir, sauerkraut etc. they are beneficial to their host and help balance the gut environment. Probiotics produce short chain fatty acids in the colon, which acidify the environment. Lower colon pH is associated with lower incidence of colon cancer.

VITAMIN D
Vitamin D is produced primarily from the exposure of the skin to sunshine. Even casual exposure of the face, hands, and arms in the summer generates a large amount of vitamin D.
The concentration of the active hormonal form of vitamin D is tightly regulated in the blood by the kidneys. This active hormonal form of vitamin D has the potent anti-cancer properties.

HIGH AMOUNTS OF SALTED FOODS
Eating large amounts of salted foods, such as salt preserved fish, is associated with an increased risk; this might be caused by the salt itself or by carcinogens derived from the nitrites in many preserved foods. Salted food might increase the risk of Helicobacter pylori infection (an established cause of stomach cancer.

SUMMARY
Your food choices and lifestyle could probably predispose you to the risk of developing various types of cancers, especially gut related cancers .
Lifestyle modification can’t really be over emphasized when it comes to healthy living.

SOURCES: https://www.bmj.com/content/368/bmj.m511
https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-3-19
https://www.health.harvard.edu/cancer/cancer-and-diet-whats-the-connection

The talk about gut health and hormones isn’t yet hitting the internet as it should. Rather, everyone is more concerned about their shape and the size of their belly. Your gut and hormones are intrinsically connected and affect your health in ways you can’t imagine.
This write up helps explain the link between your gut and hormones.

What Is The Estrobolome?
The estrobolome is a collection of bacteria in the gut which is capable of metabolising and modulating the body’s circulating estrogen. It is the bacteria in the gut, and the estrobolome, that affects estrogen levels, which in turn can impact weight, libido and mood. The estroblome modulates the enterohepatic circulation of estrogens and affects circulating and excreted estrogen levels.

Hormones And Gut Health: Why should I care about my Gut Health?
Scientific research has demonstrated that gut microbes regulate many aspects of human physiology, including intestinal permeability, the absorption of nutrients from food, and immunity.

Optimising our gut health is key to keeping our hormones in balance. Gut health is so important because the microbiome has many functions as listed below:
• Aids the synthesis and regulation of hormones and neurotransmitters
• Facilitates absorption of macro and micronutrients
• Has an essential role in the immune system
• Contributes to regulation of estrogen levels in the body
Estrogens are primarily made in the ovaries and adrenal glands. There are three different types, which are Estradiol, Estriol, and Estrone. All of which have vital roles in the body. In women, estrogens help regulate body fat, are essential to female reproductive function, cardiovascular health, bone health, and brain function (including memory). In men, estrogens aid in the maturation of sperm and maintenance of libido, oh yes! Male folks has estrogen too.
When the gut microbiome is healthy, the estrobolome is producing optimal levels of an enzyme called betaglucuronidase – there is an imbalance in estrogen when there is too much production of this enzyme.
Betaglucuronidase also has an important role in breaking down complex carbohydrates and the absorption of bilirubin and flavonoids. A healthy, diverse gut microbiome with a rich collection of different bacteria is critical for hormonal balance.
A healthy estrobolome minimises reabsorption of estrogen from the gut allowing safe removal as waste in stool and urine again ensuring hormone balance.
Gut dysbiosis is an imbalance of the gut bacteria in the gastrointestinal tract. Elevated betaglucuronidase levels are associated with conditions including:
• Pre-menstrual syndrome (PMS)
• Obesity
• Metabolic syndrome
• Estrogen-related cancers (breast and prostate)
• Endometriosis
• Infertility
• Mood swings (the feel good hormones are produced in the gut, if the gut is not healthy, it sends wrong signals)
• Heart disease
Unfortunately, gut dysbiosis and gut microbiome imbalance are very common and the delicate balance of the microbiome and estrobolome can be affected by many different factors which include genetics, age, weight, diet, alcohol, antibiotics, environmental pollutants and more.

Signs of an Unhealthy Gut
There are many signs of an unhealthy gut, which can often be misdiagnosed as something else.
• Digestive issues (bloating, gas, diarrhoea or constipation)
• Weight changes
• Food sensitivities
• Fatigue
• Skin irritation
• Autoimmune conditions
• Hormonal imbalance

Factors that affect Gut Health And Hormone Balance
To correct hormone imbalance, there are ways to ensure that the gut stays healthy and those ways include:
1. Dietary considerations
“The food we eat not only feeds our cells, but also determines what kind of inner garden we are growing in our guts.” – Dr. Mark Hyman.
Well, the saying “you are what you eat” comes to limelight here. Diet plays a vital role in shaping our gut microbiome. A low GI (glycaemic index) diet which contains a diverse range of fruit, vegetables and fibre, high in phytonutrients – the so-called ‘rainbow plate’ – can encourage microbial diversity.
It is important to go moderate on what is referred to as ‘white carbs’ such as pasta, rice and potatoes which contain resistant starch; a type that promotes healthy gut. Cutting them out totally would mean cutting out the sources of resistant starch.
Bear in mind that cruciferous vegetables, such as broccoli, contain compounds that ease detoxification of estrogen. The supplement DIM (diindolylmethane) contains concentrates of such compounds and can be effective in lowering more toxic estrogen byproducts.
Prebiotics and probiotics should also be considered. Prebiotic foods such as garlic, onion, asparagus and bananas provide the material that gut bacteria like to feed on. Probiotic foods such as kefir, kombucha, kimchi, plain yoghurt and other fermented foods are really useful for introducing beneficial bacterial strains, like lactobacillus, to the gut.
It’s important to note that the supplement calcium D glucarate is a betaglucuronidase inhibitor and allows estrogen to remain conjugated, and therefore safely eliminated by intestinal detoxification.
2. Your environment matters a lot
Phytoestrogens from plants such as soya, tofu and tempeh are consumed as food while others are synthetically manufactured and called Xenoestrogens. These are found in common household products such as fragrances, pesticides and plastics, and can easily be obtained from the environment around us. It is important to find ways of reducing these toxic substances that impact our health and find more environmentally friendly solutions. Xenoestrogens are absorbed by the body and stored in liver and fat cells. They act synergistically with endogenously produced estrogens and influence cell proliferation and disrupt the delicate balance of hormones.
3. Antibiotics
So many people abuse antibiotics, if not prescribed, please desist from using them. The use of antibiotics disrupts the ecology of the gut microbiome, and can cause overgrowth or dysbiosis. A study by the University of Copenhagen found that six months after stopping antibiotics, most healthy people can recover the microbiome composition and function. However, the gut can still lack some of the beneficial bacteria and we then need to reintroduce the good guys!
4. Alcohol
No one really wants to hear that overconsumption of alcohol is detrimental to the health. Our society has made it look like consuming alcohol doesn’t make you vulnerable at all. But alcohol consumption can have a negative impact, not only on the gut microbiome but also on the liver and its ability to detoxify. This contributes to estrogen dominance symptoms and an increased risk of estrogen related cancers. Its festive season and you must unwind with friends and families, so we won’t put a knife to your throat not to take alcohol. 1 drink a day for women and 2 drinks a day for men( 1 drink equates 12 ounces of beer, 8 ounces of malt liquor, 5 ounces of wine, 1.5 ounces of distilled spirits and liquor). A single large glass of wine can contain up to 3 units of alcohol!
5. Physical activity
Physical activity can never be overemphasised. Exercise is an excellent way to support the detoxification that happens in the liver. Regular, moderate intensity exercise can lower levels of circulating estrogens. It can also reduce the stress hormone, cortisol, which can have a negative impact on our sex hormones. However, we do need to be mindful of individuality as different people have different stress levels/thresholds. Activities that stimulate the parasympathetic nervous system or the body’s ‘rest and digest’ mode, such as yoga, are also very beneficial to hormonal health and keeps the hormones balanced.
Summary
Lifestyle, nutrition, physical activity and stress management all play important roles in helping to balance your estrobolome and also ensuring that we keep our hormones balanced and optimal.

Does Body Weight Affect Cancer Risk?

Being overweight, obese or having a BMI over 30kgmsq (since the society wants to scrap out the word obese) seems to be  linked to an overall increased risk of cancer. According to research from the American Cancer Society, excess body weight is thought to be responsible for about 11% of cancers in women and about 5% of cancers in men in the United States, as well as about 7% of all cancer deaths.  

Being overweight or obese is clearly linked with an increased risk of 13 types of cancer, which includes:

• Breast cancer (in women past menopause)
• Colon and rectal cancer (diet related)
• Endometrial cancer (cancer of the lining of the uterus)
• Esophagus cancer (diet related)
• Gallbladder cancer (diet related)
• Kidney cancer (diet related)
• Liver cancer (diet related)
• Ovarian cancer
• Pancreas cancer (diet related)
• Stomach cancer (diet related)
• Thyroid cancer (diet related)
• Multiple myeloma
• Meningioma (a tumor of the lining of the brain and spinal cord). Notice that there is a correlation with diet and almost 80% of all stated cancers. Most part of your body more vulnerable to cancers are the ones exposed to whatever dietary choices you make.

Being overweight or obese might also raise the risk of other cancers, such as:

• Non-Hodgkin lymphoma
• Male breast cancer
• Cancers of the mouth, throat, and voice box
• Aggressive forms of prostate cancer

The bond between cancer and  body weight is stronger for some cancers than for others. For example, excess body weight is thought to be a factor in more than half of all endometrial cancers, whereas it is linked to a smaller portion of other cancers.

Understanding the link between body weight and cancers is quite complex and might tip you off balance a bit. For example, while studies have found that excess weight is linked with an increased risk of breast cancer in women after menopause, it does not seem to increase the risk of breast cancer before menopause. Reasons best known to science (giggles).

The time of an individual’s life in which they gain weight might also affect cancer risk. Being overweight during childhood and young adulthood might be more of a risk factor than gaining weight later in life for some cancers. For example, some research suggests that women who are overweight as teenagers (but not those who gain weight as adults) may be at higher risk for developing ovarian cancer before menopause.

More research still needs to be carried out to back up some of these claims 

How might body weight affect cancer risk?

Excess body weight may affect cancer risk in a number of ways, some of which might be specific to certain cancer types. Excess body fat might increase cancer risk by affecting:

• Inflammation in the body
• Cell and blood vessel growth
• Cells’ ability to live longer than they normally would
• Levels of certain hormones, such as insulin and estrogen, which can fuel cell growth
• Other factors that regulate cell growth, such as insulin-like growth factor-1 (IGF-1)
• The ability of cancer cells to spread (metastasize)

Does losing weight reduce cancer risk?

Research on how losing weight might lower the risk of developing cancer is limited. Still, there’s growing evidence that weight loss might reduce the risk of some types of cancer, such as breast cancer (after menopause) and endometrial cancer.

Some body changes that occur as a result of weight loss suggest it may, indeed, reduce cancer risk. For example, overweight or obese people who intentionally lose weight have reduced levels of certain hormones that are related to cancer risk, such as insulin, estrogens, and androgens.

While we still have much to learn about the link between weight loss and cancer risk, people who are overweight or obese should be encouraged and supported if they try to lose weight. Aside from possibly reducing cancer risk, losing weight can have many other health benefits, such as lowering the risk of heart disease and diabetes. Losing even a small amount of weight has health benefits and is a good place to start.

It’s important to lose body weight, but much more important to lose body fat rather than just water fat (glycogen stores). So rather than cutting out carbs with chain saws and axes, reduce the amount of trans fat and ensure you take in quality nutrients. 

The science around it all

Overall, the majority of hypotheses proposed over the past 20–30 years have been based around the physiological functions and pathological correlations of compounds intimately involved in general metabolism of adipose tissue or its regulation by systemic factors and the relevance of those compounds to cell proliferation or development that could contribute to abnormal proliferation and migration leading to oncogenesis (development of tumors). The more recently developed concepts to be described below adopt a wider perspective in which the interface between adipose metabolism, inflammation and carcinogenesis is mediated by newly uncovered links involving biochemical pathways which open new perspectives on the obesity/cancer relationship in a more holistic, biologically integrated manner.

 These ideas include the inflammation-induced activation of the kynurenine pathway and its role in feeding and metabolism by activation of the aryl hydrocarbon receptor (AHR) and by modulating synaptic transmission in the brain. Evidence for a role of the kynurenine pathway in carcinogenesis then provides a potentially major link between obesity and cancer. A second new hypothesis is based on evidence that serine proteases can deplete cells of the tumour suppressors Deleted in Colorectal Cancer (DCC) and neogenin. These enzymes include mammalian chymotryptic proteases released by pro-inflammatory neutrophils and macrophages.

The kynurenine pathway represents the dominant pathway of tryptophan catabolism, accounting for the disposal of around 95% of the tryptophan not used for protein synthesis.

According to a research carried out by Jin in 2015, he stated and i quote that “the relevance of the kynurenine pathway is that not only do its components affect the regulation of metabolism, feeding and body mass, largely via the modulation of NMDA receptor activity, but they are also implicated in aspects of carcinogenesis’. Expression of the central enzyme of the pathway – kynurenine-3-monooxygenase (KMO) is greater in human hepatic carcinoma cells than controls and is known to influence cell proliferation and migration.

Other factors like insulin resistance, high glucagon and leptin levels (in obese and diabetic patients), adipokines (adiponectin) which is reduced in obese patients, highly concentrated levels of ceruloplasmin in adipose tissues of obese patients, might also increase an obese patients risk to several types of cancer. 

Dietary consideration 

Bowman-Birk inhibitors are relatively small proteins found in plant based foods, highly stable within the intestine and generally resistant to heating and cooking, which are known to be absorbed from the intestine into the blood. 

Several studies suggest that the presence of bowman’s birk inhibitors (BBI) are capable of inducing apoptosis in human breast carcinoma. The BBI is also capable of suppressing carcinogenic processes that include colon, oral leukoplakia, esophageal tumors, leukemia, prostatic hyperplasia and breast cancer (quite elusive though).

An overall healthy diet and lifestyle cannot be over emphasized, whether you choose a ‘only plant based diet’ or you choose to do a variety, make sure you do the right thing for your body MODERATION! 

Sources: https://www.nature.com/articles/cddiscovery201567

https://www.cancer.org/cancer/cancer-causes/diet-physical-activity/body-weight-and-cancer-risk/effects.html

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952217/

The happiest moments in a family and couple’s life is that period when the wife is heavy with child. Everyone is expectant, and also,everyone has one advice to give; especially dietary. 

One of those many advice is the intake of pineapples during pregnancy;so many claims that pineapple contains ‘bromelain’ ( a protein digesting enzyme), which poses a threat of  miscarriage or induces premature labour on the woman. 

BROMELAIN 

Bromelain is a protein-digesting enzyme mixture derived from the stem, fruit, and juice of the pineapple plant. It has a centuries-long history of being used to treat medical ailments, primarily throughout Central and South America.

It is currently categorized as a dietary supplement, and generally recognized as safe (GRAS) by the U.S. Food and Drug Administration (FDA).

Bromelain may be used alone or in conjunction with other medications. People use bromelain topically, to remove dead skin from burns, and orally, to reduce inflammation and swelling — particularly of the nasal passages.

Bromelain is also used as a digestive aid, for osteoarthritis, and to reduce soreness in aching muscles.

Potential health benefits

Bromelain and its potential health benefits have been studied extensively in multiple areas. These include:

1. Osteoarthritis 

Clinical studies found that bromelain’s anti-inflammatory and analgesic properties make it an effective treatment for the pain, soft-tissue swelling, and joint stiffness associated with osteoarthritis.

The review focused on bromelain’s effectiveness in treating arthritis of the knee and shoulder. The studies analyzed varied significantly in terms of dosage. Improvements were found in some study participants given 400 milligrams of bromelain, two times daily.

2. Cardiovascular disease

A source  reported that bromelain was effective at treating cardiovascular diseases, such as peripheral artery disease, stroke, heart attack, and high blood pressure.

Bromelain inhibits the ability of blood platelets to stick or clump together (aggregation). This may help reduce clot formation and cardiovascular events.

3. Asthma

The results of an animal study indicated that bromelain’s anti-inflammatory effects might be beneficial to people with asthma or other forms of allergic airway disease.

4. Chronic sinusitis (chronic rhinosinusitis)

A pilot study found that bromelain tablets were effective at alleviating swelling, congestion, and other symptoms associated with chronic sinusitis. Study participants were given bromelain daily for a 3-month period.

5. Colitis

An animal study found that purified fruit bromelain reduced inflammation and healed mucosal ulcers caused by inflammatory bowel disease in rats.

6. Burns

A study review found that bromelain, when used as a topical cream, was highly effective at safely removing damaged tissue from wounds and from second- and third-degree burns.

7. Cancer

A 2010 study  indicated that bromelain shows promise in combating cancer. Bromelain may have the ability to positively impact cancer cell growth, and it may help to control the key pathways supporting malignancy.

NUTRITION 

Positive nutritional effects have been shown in bedridden, tube-fed, nursing home patients who received a supplementary digestive aid containing bromelain plus an extract of Aspergillus niger. Total protein concentration improved significantly with the supplement (P < 0.02), which was reversed after withdrawal.

DOSAGE 

Two slices of pineapple contain approximately 100 mg of ascorbic acid (vitamin C), approximately the recommended daily adult intake. Commercially available bromelain supplements contain predominantly stem bromelain, as compared with fruit bromelain.

The usual dosage of bromelain is 40 mg 3 or 4 times daily. However, because bromelain is regarded as being relatively nontoxic, doses of up to 2,000 mg/day have been used.Most commercial products contain bromelain 500 mg; manufacturers suggest a dosage regimen of 500 to 1,000 mg daily.

PREGNANCY 

Information regarding safety and efficacy in pregnancy and lactation is lacking. Clinical evidence to support the traditional use of pineapple as an emmenagogue and abortifacient is limited. Previously, bromelain/trypsin (as Kimotab) was investigated for use in breast engorgement during lactation.

A cup or two of pineapple juice per week won’t do any harm to mother or foetus, rather it supplies a lot of benefits as: 

• 2 slices of pineapple contains about 100mg of vitamin C which is a bit above the daily value for pregnant women (85mg/day). Vitamin c helps repair and prevent cell damage by warding off free radicals. 
• Contains manganese which helps build strong bones and connective tissues 
• Might be helpful in preventing osteoporosis in post menopausal women

HEALTH RISKS

Because pineapples contain a whole lot of vitamin c, overconsumption may lead to diarrhoea, abdominal pain, nausea and heartburn for some people. 

Additionally, extremely high amounts of bromelain can cause skin rashes, vomiting, diarrhea, and excessive menstrual bleeding, according to the University of Maryland Medical Center. Bromelain can also interact with some medications. Those taking antibiotics, anticoagulants, blood thinners, anticonvulsants, barbiturates, benzodiazepines, insomnia drugs and tricyclic antidepressants should be careful not to eat too much pineapple.  

SOURCES: https://www.drugs.com/npp/pineapple.html

https://www.livescience.com/45487-pineapple-nutrition.html

https://www.healthline.com/health/bromelain#health-benefits

There seems to be a lot of debate out there about artificial sweetners.

Some research says its good for weightloss and as a good substitute for table sugars, while some say it would increase the risk of  cancer and also increase blood sugar level.

Well, lets dive into this troubled waters and see what we can pull out of it shall we?

What Are Artificial Sweeteners?

Artificial sweeteners, or sugar substitutes, are chemicals added to some foods and beverages to make them taste sweet.

They tend to provide a taste that seems 1,000 times sweeter than regular sugar.

Although some sweeteners contain calories, the amount needed to sweeten products is so small that you end up consuming almost no calories.

They are mostly used in beverages and drinks since they provide zero calories.

How Do Artificial Sweeteners Work?

The surface of your tongue is covered by many taste buds. Each taste bud contains several taste receptors that detect different flavors ( sweet, sour, salty).

Each time you eat, the different food molecules contact your taste receptors.

When the food molecule meets with the receptor, it (receptor) sends a signal to your brain, allowing you to identify the taste

For example, the sugar molecule fits perfectly into the taste receptor for sweetness, like a missing pixzle piece  allowing your brain to identify the sweet taste.

The molecules of artificial sweeteners are similar enough to sugar molecules that they fit on the sweetness receptor.

However, they are generally too different from sugar for your body to break them down into calories. This is why they have a sweet taste without the added calories.

Only a minority of artificial sweeteners have a structure that your body can break down into calories. Because only very small amounts of artificial sweeteners are needed to make foods taste sweet, you consume virtually no calories.

Reason why they won’t provide calories (energy) is because your body cannot break them down.

What Are the Names of Artificial Sweeteners?

The following artificial sweeteners are allowed for use in the US and/or the European Union:

Aspartame: 200 times sweeter than table sugar. Aspartame is known under the brand names Nutrasweet, Equal or Sugar Twin.

Acesulfame potassium: 200 times sweeter than table sugar. Acesulfame potassium is suited for cooking and baking and known under brand names Sunnet or Sweet One.

Advantame: 20,000 times sweeter than table sugar, suited for cooking and baking.

Aspartame-acesulfame salt: 350 times sweeter than table sugar, and known under the brand name Twinsweet.

Cyclamate: 50 times sweeter than table sugar. Cyclamate is suited for cooking and baking. However, it’s been banned in the US since 1970.

Neotame: 13,000 times sweeter than table sugar. Neotame is suited for cooking and baking and known under the brand name Newtame.

Neohesperidin: 340 times sweeter than table sugar. It is suited for cooking, baking and mixing with acidic foods. It is not approved for use in the US.

Saccharin: 700 times sweeter than table sugar. It’s known under the brand names Sweet’N Low, Sweet Twin or Necta Sweet.

Sucralose: 600 times sweeter table sugar. Sucralose is suited for cooking, baking and mixing with acidic foods. It’s known under the brand name Splenda.

There’s also a new guy om the block called ‘allulose’ made from grains.

Effects on Appetite

Some people believe artificial sweeteners might actually increase appetite and promote weight gain .

Because they taste sweet but lack the calories found in other sweet-tasting foods, they’re thought to confuse the brain into still feeling hungry after consumption.

Additionally, some scientists think you’d need to eat more of an artificially sweetened food, compared to the sugar-sweetened version, in order to feel full; well, who knows?

Although these theories are plausible, there’s mo back up claim whatsoever to them.

Effect on weight

Well, we have seen that artificial sweetners do not contain calories at all, so obvioulsy they wont increase your risk of gaining extra pounds.

But once they increase your sugar cravings, its better you stick to water than that can of soda.

Effects on diabetes

Artificial sweetners would reduce your intake of refined sugar, thereby making it easy for your insulin levels to work. It doesnt have any adverse effects on your glucose yes, but it is better you seek advice from your dietitan or doctor before using them.

Effect on gut health

The health of your gut totally determines if you would be vulnerable to certain illness.

Once your gut is not happy with you, you are at risk of poor blood sugar control,  weakened immune system, and disrupted sleep.

Some studies suggest that selected sweetners could disrupt the health of your gut by affecting the balance of gut bacteria.

Artificial sweetners and cancer

Apart from cyclamate which was banned in 1970 in America, no other other study has linked artificial sweetners with cancer.

Artificial sweetners and Dental health

Unlike sugars, artificial sweetners do not react with bacteria in your mourh to form acids. So, they dont affect your dental health negatively.

1. Some sweetners could cause headaches, seizures or depression in some individuals while leaving out others.

Safety and side effects

Artificial sweetners are safe to use but should not be consumed by individuals with phenylketonuria or those allergic to sulfonamides.

Take home Message for all

The use of artificial sweetners pose no threats to the health if used as alternatives to sugars.

Some risks attatched to it might be severe or different in individuals, so its best  to seek advice before selecting a sweetner.

Source: https://www.healthline.com/nutrition/artificial-sweeteners-good-or-bad#section12

NUTRITION AND CANCER
Cancer is simply termed ‘growth of unhealthy tissues (malignant) which results from abnormal or uncontrolled cell division.
Cancer occurs in all parts of the human body and has the ability to spread across (metastasize) to another region in the body.
Carcinogens are possible factors that when exposed to, can cause or promote cancer. There are both environmental and dietary factors that could be carcinogenic in nature.
Exposure to certain factors like radiation, sunlight, toxic substances from creams , and smoking could lead to cancer.
DIETARY FACTORS THAT COULD LEAD TO OBESITY
1. Abuse of alcohol could lead to mouth, throat and liver cancer.🍺🍻
2. High intakes of smoke or salt preserved foods, refined flour or starch, and processed meat🍗 could lead to stomach cancer.
3. High intake of saturated fats, red meat, and supplemental iron with reduced intake of fibre could lead to colorectal cancer. 🍖
4. Folate deficiency and low intake of dark green leafy vegetables could lead to cervical cancer.
Fruits and vegetables don’t have the ability to cure cancer but adequate consumption of them could help prevent the development of cancer. For example, the cruciferous vegetables – cabbage, cauliflower, broccoli contain phytochemical that could be beneficial in defending against colon cancer.
Maintaining a healthy body weight could also help to reduce risks of cancer in both genders👬. Obese postmenopausal women are at the risk of developing breast cancer because fat tissues produces oestrogen and extended exposure of this oestrogen in obese postmenopausal women is linked to an increased risk of developing breast cancer.
DIETARY RECOMMENDATIONS FOR REDUCING CANCER RISKS
1. Maintain a healthy body weight by eating small portions of foods, balancing energy intake with physical activities and choosing healthy fats
2. Eat at least 5 servings of fruits and vegetables daily.
3. Choose lean meats, fish and poultry as alternatives to pork and processed meats as hot dogs and sausages.
4. If you must take alcohol, limit it to 2 drinks per day.
5. Choose whole grains like oats, whole wheat bread instead of pastries and breakfast cereals.

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Well, today is cancer day and I thought it wise to bring to you guys a lay-mans summary of cancer; something that explains it in terms you guys would be able to relate easier to. Here you go:

Defining Cancer

• Carcinoma– cancer that begins in the skin or in tissues that line or cover internal organs. There are a number of subtypes of carcinoma, includingadenocarcinoma,basal cell carcinoma,squamous cell carcinoma, andtransitional cellcarcinoma.
• Sarcoma– cancer that begins in bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue.
• Leukemia– cancer that starts in blood-forming tissue such as the bone marrow and causes large numbers of abnormal blood cells to be produced and enter the blood.
• Lymphoma and myeloma– cancers that begin in the cells of theimmune system.
• Central nervous system cancers– cancers that begin in the tissues of the brain and spinal cord.

Origins of Cancer

All cancers begin in cells, the body’s basic unit of life. To understand cancer, it’s helpful to know what happens when normal cells become cancer cells.

The body is made up of many types of cells. These cells grow and divide in a controlled way to produce more cells as they are needed to keep the body healthy. When cells become old or damaged, they die and are replaced with new cells.

However, sometimes this orderly process goes wrong. The genetic material (DNA) of a cell can become damaged or changed, producingmutationsthat affect normal cell growth and division. When this happens, cells do not die when they should and new cells form when the body does not need them. The extra cells may form a mass of tissue called atumor.

(Image from Understanding Cancer Series: Cancer.)

Not all tumors are cancerous; tumors can be benign or malignant.

• Benign tumorsaren’t cancerous. They can often be removed, and, in most cases, they do not come back. Cells in benign tumors do not spread to other parts of the body.
• Malignant tumorsare cancerous. Cells in these tumors can invade nearby tissues and spread to other parts of the body. The spread of cancer from one part of the body to another is called metastasis.

Some cancers do not form tumors. For example, leukemia is a cancer of the bone marrow and blood.

What are the symptoms of cancer?

Cancer symptoms are quite varied and depend on where the cancer is located, where it has spread, and how big the tumor is. Some cancers can be felt or seen through the skin – a lump on the breast or testicle can be an indicator of cancer in those locations. Skin cancer (melanoma) is often noted by a change in a wart or mole on the skin. Some oral cancers present white patches inside the mouth or white spots on the tongue.

Other cancers have symptoms that are less physically apparent. Some brain tumors tend to present symptoms early in the disease as they affect important cognitive functions. Pancreas cancers are usually too small to cause symptoms until they cause pain by pushing against nearby nerves or interfere with liver function to cause a yellowing of the skin and eyes called jaundice. Symptoms also can be created as a tumor grows and pushes against organs and blood vessels. For example, colon cancers lead to symptoms such as constipation, diarrhea, and changes in stool size. Bladder or prostate cancers cause changes in bladder function such as more frequent or infrequent urination.

As cancer cells use the body’s energy and interfere with normal hormone function, it is possible to present symptoms such as fever, fatigue, excessive sweating, anemia, and unexplained weight loss. However, these symptoms are common in several other maladies as well. For example, coughing and hoarseness can point to lung or throat cancer as well as several other conditions.

When cancer spreads, or metastasizes, additional symptoms can present themselves in the newly affected area. Swollen or enlarged lymph nodes are common and likely to be present early. If cancer spreads to the brain, patients may experience vertigo, headaches, or seizures. Spreading to the lungs may cause coughing and shortness of breath. In addition, the liver may become enlarged and cause jaundice and bones can become painful, brittle, and break easily. Symptoms of metastasis ultimately depend on the location to which the cancer has spread.

How cancer spreads–

scientists reported inNature Communications(October 2012 issue) that they havediscovered an important clue as to why cancer cells spread. It has something to do with their adhesion (stickiness) properties. Certain molecular interactions between cells and the scaffolding that holds them in place (extracellular matrix) cause them to become unstuck at the original tumor site, they become dislodged, move on and then reattach themselves at a new site.

The researchers say this discovery is important because cancer mortality is mainly due to metastatic tumors, those that grow from cells that have traveled from their original site to another part of the body. Only 10% of cancer deaths are caused by the primary tumors.

The scientists, from the Massachusetts Institute of Technology, say that finding a way to stop cancer cells from sticking to new sites could interfere with metastatic disease, and halt the growth of secondary tumors.

How is cancer diagnosed and staged?

Early detection of cancer can greatly improve the odds of successful treatment and survival. Physicians use information from symptoms and several other procedures to diagnose cancer. Imaging techniques such as X-rays, CT scans, MRI scans, PET scans, and ultrasound scans are used regularly in order to detect where a tumor is located and what organs may be affected by it. Doctors may also conduct an endoscopy, which is a procedure that uses a thin tube with a camera and light at one end, to look for abnormalities inside the body.

Extracting cancer cells and looking at them under a microscope is the only absolute way to diagnose cancer. This procedure is called a biopsy. Other types of molecular diagnostic tests are frequently employed as well. Physicians will analyze your body’s sugars, fats, proteins, and DNA at the molecular level. For example, cancerous prostate cells release a higher level of a chemical called PSA (prostate-specific antigen) into the bloodstream that can be detected by a blood test. Molecular diagnostics, biopsies, and imaging techniques are all used together to diagnose cancer.

After a diagnosis is made, doctors find out how far the cancer has spread and determine the stage of the cancer. The stage determines which choices will be available for treatment and informs prognoses. The most common cancer staging method is called the TNM system. T (1-4) indicates the size and direct extent of the primary tumor, N (0-3) indicates the degree to which the cancer has spread to nearby lymph nodes, and M (0-1) indicates whether the cancer has metastasized to other organs in the body. A small tumor that has not spread to lymph nodes or distant organs may be staged as (T1, N0, M0), for example.

TNM descriptions then lead to a simpler categorization of stages, from 0 to 4, where lower numbers indicate that the cancer has spread less. While most Stage 1 tumors are curable, most Stage 4 tumors are inoperable or untreatable.

How is cancer treated?

Cancer treatment depends on the type of cancer, the stage of the cancer (how much it has spread), age, health status, and additional personal characteristics. There is no single treatment for cancer, and patients often receive a combination of therapies and palliative care. Treatments usually fall into one of the following categories: surgery, radiation, chemotherapy, immunotherapy, hormone therapy, or gene therapy.